Search results for "Bipolar depression"

showing 3 items of 3 documents

Atypical Antipsychotics in the Treatment of Acute Bipolar Depression with Mixed Features: A Systematic Review and Exploratory Meta-Analysis of Placeb…

2016

Evidence supporting the use of second generation antipsychotics (SGAs) in the treatment of acute depression with mixed features (MFs) associated with bipolar disorder (BD) is scarce and equivocal. Therefore, we conducted a systematic review and preliminary meta-analysis investigating SGAs in the treatment of acute BD depression with MFs. Two authors independently searched major electronic databases from 1990 until September 2015 for randomized (placebo-) controlled trials (RCTs) or open-label clinical trials investigating the efficacy of SGAs in the treatment of acute bipolar depression with MFs. A random-effect meta-analysis calculating the standardized mean difference (SMD) between SGA an…

Bipolar DisorderManic-depressive illness--Treatmentmeta-analysilcsh:ChemistryClinical trials0302 clinical medicineManic-depressive illnessAsenapineAntipsychotic drugslcsh:QH301-705.5Spectroscopydiagnostic and statistical manual for mental disorders fifth edition (DSM-5)PsychiatryDepressionBrief ReportGeneral MedicineComputer Science ApplicationsTreatment OutcomeMeta-analysismixed featureHumanmedicine.drugAntipsychotic Agentsmedicine.medical_specialtyAcute bipolar depression; Diagnostic and statistical manual for mental disorders fifth edition (DSM-5); Meta-analysis; Mixed features; Second generation antipsychotic (SGA); Systematic-review; Physical and Theoretical Chemistry; Organic Chemistry; Spectroscopy; Inorganic Chemistry; Catalysis; Molecular BiologyYoung Mania Rating ScalePlaceboCatalysisInorganic Chemistry03 medical and health sciencessystematic-reviewInternal medicinemedicineHumansZiprasidoneBipolar disorderPhysical and Theoretical ChemistryPsychiatryMolecular BiologyLurasidonemixed featuresbusiness.industryOrganic Chemistrysecond generation antipsychotic (SGA)acute bipolar depressionmedicine.disease030227 psychiatrymeta-analysisAntipsychotic Agentlcsh:Biology (General)lcsh:QD1-999QuetiapineControlled Clinical Trials as Topicbusiness030217 neurology & neurosurgeryInternational Journal of Molecular Sciences
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Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews

2017

Introduction. A burgeoning number of systematic reviews considering lurasidone in the treatment of bipolar depression have occurred since its Food and Drug Administration extended approval in 2013. While a paucity of available quantitative evidence still precludes preliminary meta-analysis on the matter, the present quality assessment of systematic review of systematic reviews, nonetheless, aims at highlighting current essential information on the topic. Methods. Both published and unpublished systematic reviews about lurasidone mono- or adjunctive therapy in the treatment of bipolar depression were searched by two independent authors inquiring PubMed/Cochrane/Embase/Scopus from inception u…

Genetics and Molecular Biology (all)Transtorno Bipolarmedicine.medical_specialtyBipolar DisorderImmunology and Microbiology (all)ConcordanceDrug profileAlternative medicineMEDLINElcsh:MedicineReview ArticleBiochemistryGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesLurasidone Hydrochloride0302 clinical medicineImmunology and Microbiology (all); Biochemistry Genetics and Molecular Biology (all)medicineBipolar DepressionHumansPsychiatryDrug ApprovalDepression (differential diagnoses)LurasidoneGeneral Immunology and Microbiologybusiness.industrylcsh:RGeneral Medicine030227 psychiatrySystematic reviewTolerabilityDepressãobusiness030217 neurology & neurosurgerymedicine.drugLurasidone
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Lamotrigine compared to placebo and other agents with antidepressant activity in patients with unipolar and bipolar depression: a comprehensive meta-…

2016

ObjectivesTo meta-analytically summarize lamotrigine’s effectiveness and safety in unipolar and bipolar depression.MethodsWe conducted systematic PubMed and SCOPUS reviews (last search =10/01/2015) of randomized controlled trials comparing lamotrigine to placebo or other agents with antidepressant activity in unipolar or bipolar depression. We performed a random-effects meta-analysis of depression ratings, response, remission, and adverse effects calculating standardized mean difference (SMD) and risk ratio (RR) ±95% confidence intervals (CIs).ResultsEighteen studies (n=2152, duration=9.83 weeks) in patients with unipolar depression (studies=4, n=187; monotherapy vs lithium=1, augmentation …

Olanzapinemedicine.medical_specialtyBipolar DisorderLithium (medication)Bipolar depressionBipolar depression bipolar disorder lamotrigine major depressive disorder trials unipolar depressionCitalopramLithiumCitalopramLamotrigineLamotriginePlaceboBipolar depression; bipolar disorder; lamotrigine; major depressive disorder; trials; unipolar depressionBenzodiazepines03 medical and health sciences0302 clinical medicineAntimanic AgentsFluoxetineInternal medicinemedicineHumansBipolar disorderunipolar depressionPsychiatryDepressive Disorder MajorFluoxetinemajor depressive disorderDepressionTriazinesbusiness.industrytrialsmedicine.diseaseAntidepressive Agents030227 psychiatryDrug CombinationsPsychiatry and Mental healthVitamin B ComplexMajor depressive disorderAnticonvulsantsNeurology (clinical)businessInositol030217 neurology & neurosurgeryAntipsychotic Agentsmedicine.drug
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